Xavier's Institute for Mutant Education and Outreach is located within Central Park. Kitty Pryde is the current acting headmistress.

Headquarters of the hit New York newspaper, and workplace of one Peter Parker. Notorious for its heavy handed bias against the exploits of Spider-Man, the publication constantly edged out rival the Daily Globe to be the most read newspaper of New York City.

The current headquarters of the Fantastic Four. The facade appears nothing more than an exceptionally narrow brownstone with a 4 sign above the door. Inside are the living quarters for the F4, as well as their typical hi-tech, team-related lair.

Located at 721 Fifth Avenue, this three-story townhouse was originally built in 1932 by industrialist Howard Stark as his Manhattan residence. Eventually, it was donated by Tony Stark. The mansion, originally the Avengers' headquarters, is presently used by members of the Avengers Unity Division, also called the "Uncanny Avengers," since the core team's HQ moved.

The offical secret headquarters for the Young Avengers! Inside is an archery range, weapons storage, and an assortment of other necessities for these young heroes.

Hell's Kitchen, also known as Clinton and Midtown West, is a neighborhood of Manhattan in New York City that includes roughly the area between 34th street and 57th street, and from 8th avenue to the Hudson river. Daredevil is Hell's Kitchen's resident hero.

The home of the Inhumans, New Attilan stands as an island in the Hudson River along the New York/New Jersey border of the Upper New York Bay. It is the homestead of the Inhuman people, currently ruled by Iso.

Doctor Stephen Strange's mansion is located in Greenwich Village at 177A Bleecker Street. His Sanctum Sanctorum is located within the mansion. Currently, an illusion disguises it as condemned and to be replaced by a Starbucks.